Web10 Apr 2024 · NFT, neurofibrillary tangles; TMG, Thiamet-G. 4 DISCUSSION. Herein, we established a platform to study sAD using human iPSC-derived cortical neurons by … WebTreatment with the OGA inhibitor Thiamet-G (TMG), silencing of OGA, or overexpression of OGA and OGT led to p53 stabilization, increased nuclear localization, and increased protein and mRNA levels of p53 target genes. These data suggest that changes in O-GlcNAc homeostasis activate the p53 pathway. Combination treatment of the chemotherapeutic ...
Regulation of Primary Cilia Length by O-GlcNAc during Neuronal ...
Web1 Oct 2024 · Increasing O-GlcNAc, either with Thiamet-G (TMG) or by suppressing the O-GlcNAcase (oga-1) gene does interfere with and, therefore, reduce Aβ- toxicity but not in … WebBiochem/physiol Actions. Thiamet G is a potent inhibitor of the enzyme O-GlcNAcase (Ki = 21 nM). The compound is orally bioavailable and crosses the blood brain barrier. Thiamet G leads to an increase in O-GlcNAc-modified proteins in cell-based and in vivo assay systems, and reduces levels of phosphorylated Tau protein in rat cortex and ... pay housing deposit university of pittsburgh
Age-related elevation of O-GlcNAc causes meiotic arrest and ...
Web26 Jan 2024 · The dynamic posttranslational modification O-linked N-acetylglucosamine (O-GlcNAc), which is a type of monosaccharide modification, has been shown to drive the process of aging in various systems, but it has not yet been investigated in the testis and male reproductive aging. Web1 Dec 2024 · Background: Thiamet-G (TMG) has recently been examined in human Alzheimer's Disease (AD) clinical trials. TMG increases total O-GlcNAc levels through inhibition of O-GlcNAcase (OGA). Web30 Nov 2024 · A pilot study was performed to identify the effective Thiamet-G (TMG; HY-12588, MedChemExpress) dose to use for the intranasal treatment. This preliminary dose … screwfix malton telephone number