Simon's minimax two-stage design
WebbAbstract. This article describes a new Stata command called simontwostage, which calculates the critical values and sample sizes for two-stage designs for phase II oncology trials.Options are provided to determine the minimax and optimal designs proposed by Simon (1989, Controlled Clinical Trials 10: 1–10) and admissible designs described by … Webb1 aug. 2001 · A two-stage design is defined by the number of patients to be accrued at each stage ( n1 and n2) and the boundary values at stages 1 and 2 ( r1 and r ). Let p0 denote the maximum unacceptable probability of response and p1 denote the minimum acceptable probability of response ( p0 < p1 ).
Simon's minimax two-stage design
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WebbDescription Calculates Optimal and Minimax 2-stage Phase II designs given by Richard Simon Usage ph2simon (pu, pa, ep1, ep2, nmax=100) # S3 method for ph2simon print (x, … Webbpractically synonymous with the Simon’s optimal and MINIMAX two stage (1989) –designs which have stood the test of time with their pracmatic trade-off between the need to stop a trial early for inefficacy if response rates were low and the likely overshoot of interim analysis in small trials.” Roger A’Hern (2014)
Webb2 u (1 p( x 1 d r 1))--- (3) Minimax Design 的目標是希望總樣本數為最小，總樣本數即為以下式(4)，故 限制式(1)、(2)再加上使得式(4)為最小的條件來求解。在此設計下所得到的總 … Webb8 juni 2024 · Simon’s two-stage design (Simon, 1989) is still one of the most often used designs in oncology phase 2 trials in single-arm trials testing a binary endpoint. After n1 patients (stage 1) the trial is …
Webb描述：计算 Richard Simon 给出的 Optimal 和 Minimax 2 阶段 Phase II 设计. 用法：ph2simon (pu, pa, ep1, ep2, nmax=100) 参数说明：. pu：不可接受的响应率. pa：理想的响应率. ep1：I类错误（alpha，α）. ep2：II类错误（beta，β）. nmax：最大总样本量（默认为 100；最多为 500）. ph2simon ... Webb15 apr. 2024 · 2 Department of Biostatistics, MD Anderson Cancer Center, Houston, TX 77030. ... Optimal Minimax. Calculate. Design Summary; Protocol Template; Reference; …
Webb20 nov. 2024 · 单臂试验Simon两阶段设计就是能很好的决定早期无效终止的一种方法。 两阶段设计，顾名思义就是把试验分成两个阶段，首先纳入较少的样本进入试验的第一阶 …
dan\\u0027s moving and storagehttp://fmwww.bc.edu/repec/bocode/s/simon2stage.html birthday treats deliveredWebbObjective To compare Gehan two-stage design and Simon two-stage design in sample size calculations for phase Ⅱ clinical trials of anti-tumor drugs. Methods We explained the sample size calculation methods with a single-stage design, Gehan two-stage design, and Simon optimal two-stage and minimax two-stage designs in line with the principle of … birthday treats deliveryWebb1 juli 2024 · Compared with the Gehan two-stage design, the Simon two-stage design has the advantage of being able to determine an early termination of trials when no or low anti-tumor activities are evident. Conclusion Simon two-stage design is better than single-stage design and Gehan two-stage design. birthday treat ideas for workWebb1 dec. 1997 · This paper extends Simon's two-stage to a three-stage design without these restrictions, and provides tables for both optimal and minimax designs. One can use the three-stage design to reduce the expected sample size when the treatment is not promising a priori and when the accrual rate is slow. birthday train themeWebbfreq_binom_one_simons_twostage is a wrapper function. It uses ph2simon from the clinfun package to generate optimal sample sizes for the the frequentist single arm, two stage designs. Frequentist and Bayesian properties are then calculated using properties_binom_one and then optimal and minimax designs are returned. Value birthday treat meaningWebb12 aug. 2024 · Simon establishes his designs by checking for every total sample size N, each possible division into two stages, those that satisfy these conditions. From these … dan\\u0027s mobile window tinting