Pten nuclear functions
WebJul 27, 2015 · The function of PTEN does not rely solely on its lipid phosphatase activity. PI(3,4,5)P 3 was shown to localize also in the nucleus and although its levels were affected by PI3K inhibitors, they remained unaffected after the expression of PTEN implying that nuclear PTEN serves another function in the cell . Indeed, localization of PTEN in the ... WebThese analyses suggest that the nuclear function of PTEN is associated with suppression of tumor development in the islets. PTEN in the nucleus may not rely on PI3K/AKT signaling to function, even though PI3K and AKT as well as PI-3,4,5-P 3 have all been observed in the nucleus [32, 88]. The lack of tumor development in β-cells lacking PTEN is ...
Pten nuclear functions
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WebFeb 1, 2024 · Lys13 and Lys289 are PTEN ubiquitination and mono-ubiquitination sites and have a role in PTEN cytoplasmic-nuclear shuttling. 58 Ubiquitin/proteasome pathway can regulate the function of PTEN. 58 NEDD4-1 is an E3 ubiquitin-protein ligase that can polyubiquitinate PTEN at Lys13 and Lys289 leading to its degradation or it can also ... WebNov 16, 2024 · While PTEN can be targeted by HECT-type E3 ubiquitin ligases for nuclear import and proteasomal degradation, studies have shown that several deubiquitinating enzymes, including HAUSP/USP7, USP10 ...
WebThis review will focus on nuclear and cytoplasmic PTEN localization. Furthermore, this … WebMar 28, 2024 · Osteoclasts (OCs), which are responsible for bone resorption, play a critical role in cholesterol-induced bone loss and recent studies have suggested that various micro-RNAs (miRs) contribute to modulating OCs. We hypothesized that 7-ketocholesterol (7-KC), a metabolite responsible for cholesterol-induced bone loss, induces miR-107-5p, which …
WebApr 15, 2015 · The N-terminal region of PTEN is important for the control of PTEN … WebMay 1, 2024 · Search life-sciences literature (41,809,309 articles, preprints and more) (41,809,309 articles, preprints and more)
WebApr 14, 2024 · PTEN is a tumor suppressor with phosphatase activity that inhibits the development of many tumors . Li et al. found that OTUD5 stabilizes PTEN through deubiquitination and that the overexpression of OTUD5 inhibits NSCLC cell proliferation, invasion and migration (Figure 3E). In cervical cancer, OTUD5 also plays an important …
WebNational Center for Biotechnology Information family court writersWebJan 12, 2007 · The PTEN tumor suppressor is frequently affected in cancer cells, and inherited PTEN mutation causes cancer-susceptibility conditions such as Cowden syndrome. PTEN acts as a plasma-membrane lipid-phosphatase antagonizing the phosphoinositide 3-kinase/AKT cell survival pathway. However, PTEN is also found in cell … cook goatWebDec 1, 2013 · Third, upon genotoxic treatment, there is an increase of RAD52 sumoylation, 3 which is required for RAD52 nuclear retention. 8 Under these genotoxic conditions, PTEN was found to be de-sumoylated and relocated from nucleus to cytoplasm, 2 which presumably causes PTEN to lose binding with Rad52. 3 Whether de-sumoylation of PTEN … cook goat headWebNov 11, 2024 · It is believed that cytoplasmic PTEN exerts its lipid phosphatase activity, while nuclear PTEN performs various cellular functions largely through lipid-phosphatase-independent mechanisms 10,12 ... cook goes in to annoy fielderWebMar 6, 2007 · Other studies have implicated the protein phosphatase functions of nuclear PTEN down-regulating mitogen-activated protein kinase pathway, as well as cyclin D1, and inducing G 1 cell cycle arrest. The regulation of p53 activity and stability by direct protein–protein interaction also occurs within the nucleus ( 100 , 119 ). family courtyard medical centre kenmoreWebAug 6, 2016 · Thus the authors concluded that nuclear PTEN may favor cell cycle arrest in the G0-G1 phase, and thus may regulate cell cycle progression [14, 35]. One of the first nuclear PTEN functions to be characterized was associated with the tumor suppressor p53. Freeman and coworkers studied the functional cross-talk between Pten and p53 in mice . cook gnocchi in fry panWebDespite the early recognition of nuclear PTEN, the understanding of the mechanisms of its nuclear localization, function in the nucleus, and importance in biology and human disease has been lacking. Over the last decade, emerging concepts for the complex involvement of nuclear PTEN in a variety of processes, including genome maintenance and DNA ... family court wynberg